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Molecular Drug Targets I. G-Protein-Coupled Receptors X. Biopharmaceutical Therapies IV. Drug Target Identification V. Hit-to-Lead VI. Clinical Biomarkers VII. Conclusion References 7.

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Historical Background III. From Screen to Lead IV. Conclusion References 8. Summary References 9. Biology Oriented Synthesis IV. Conclusion and Outlook References Data Mining Methods IV. Database Searches V. Applications VI. Conclusion and Future Directions References Fragment-Based Drug Discovery I.

What is FBDD? Nuclear Magnetic Resonance VI.

X-ray Crystallography VII. Trends for the Future References Lead-Likeness and Drug-Likeness I. Conclusion References Blogs III. Wikis IV. Compound Information V. Biological Properties of Compounds VI. Drug Information VII. Chemical Suppliers X. Chemical Synthesis XI.

Analysis XIII. Chemical Publications XIV. Patent Information XV. Toxicology XVI. Homologous Series II. Vinylogues and Benzologues References Scaffold Hopping V. Minor Metalloids-Toxic Isosters References Ring Transformations I. Analogical Approaches III. Disjunctive Approaches IV. Conjunctive Approaches V. Case studies III.

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Summary and Outlook References Preliminary Considerations III. Hit Optimization Strategies IV. Substituent Groups I. Methyl Groups III. Effects of Unsaturated Groups IV. Effects of Halogenation V. Effects of Hydroxylation VI. Basic Groups IX. Attachment of Additional Binding Sites References General Principles III. Cooperative binding References Compound Properties and Drug Quality I.

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Combinatorial Libraries III. Chemistry Control of Aqueous Solubility V. Metabolic stability VII. How Big is Chemical Space? Pharmacological Space I.

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What is Pharmacological Space? Chemical Space III. Target Space VI. Conclusions References Optical Isomerism in Drugs I. Optical Isomerism and Pharmacokinetic Effects V. Practical Considerations References The Physicochemical Challenge VI. Summary References Methodology III. Advanced approaches IV. Application study V. Statistical Tools VI. Applications IX. Conclusions and Future Directions References Protein Crystallography and Drug Discovery I. Presentation II. Examples IV. Drug Absorption IV. Drug Distribution V. Drug Elimination VI. Variability in Pharmacokinetics Bibliography Biotransformation Reactions and their Enzymes I.

Functionalization Reactions III. Conjugation Reactions IV. Project Types. Project Organization Concepts. Project Life Cycle Management. Role of Projects in the Organization. Project Success Factors. Project Initiation.

The Svalbard Passage: 3rd Edition (Unabridged)

Project Plan Development. Scope Management. Quick Start Example. Schedule Management. Cost Management. Quality Management. Resource Management. Project Communications. Project Stakeholder Management.

Project Management Theory and Practice, Third Edition - CRC Press Book

High Performance Teams. Procurement Management. Risk Management. KA Integration and Plan Completion.

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  5. Adaptive Life Cycle Models. Project Simulation. Critical Chain Model. Project Execution and Control. Change Management. Project and Enterprise Metrics. Earned Value Management. Tracking Project Progress. The Closing Process. Organizational Maturity. Project Portfolio Management. Enterprise Project Management Office. Project Governance. Projects Responsibility and Ethical Practices.

    Appendix A: Financial Metrics. Appendix B: Templates. Appendix C: Project Data Repository. Gary Richardson is the PMI endowed professor of project management at the University of Houston College of Technology graduate project management program. This program serves both the internal and external professional community in regard to the theory and practice of project management. He comes from a broad professional background including industry, consulting, government, and academia.

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